Gabriel P. López, Ph.D.
Vice President for Research
Professor, Department of Chemical & Biological Engineering
Founding Director and Member, Center for Biomedical Engineering
The University of New Mexico
Eta Diagnostics, Inc. (STC start-up)
Pucara Engineering and Logistics, LLC (STC start-up)
ieCrowd (STC start-up being spun out)
Dr. López has disclosed 53 inventions to STC, received 34 UNM-affiliated issued U. S. patents, has one pending patent application, one license agreement with company GPB Scientific, LLC, for his nanostructured devices for separation technology; one license agreement with start-up Eta Diagnostics, Inc., for his multinode parallel flow cytometry technology; one option to license with start-up Pucara Engineering and Logistics, LLC, for his bio-compatible hybrid organic/inorganic gels technology; and one option to license agreement with company ieCrowd for his modular assembly technology.
Dr. López’ nanostructured devices for separation technology is a method to fabricate nanostructured matrices for use in the separation and analysis of a wide range of biological nanostructures, including those in suspension and those associated in planar membrane-based assemblies. This invention enables the manufacture of nanostructured devices for separation based on gradient and affinity. This would be useful for sample preparation, drug discovery and proteomics, rare cell detection, and environmental sensing.
His multinode parallel flow cytometry technology is a parallel analysis system for use in flow cytometers. The system uses multinode acoustic standing waves that focus particles and cells into multiple parallel streams simultaneously with parallel optical detection across the flow streams. Acoustic wave focusing is particularly useful in parallel analysis because it can be used for a wide range of cell and particle sizes in a single device.
His bio-compatible hybrid gels technology is a novel way to immobilize cells, liposomes, enzymes, proteins and planar lipid bilayers in gels. This approach utilizes a gelling process based on vapor phase synthesis. Specimens are exposed for a specific amount of time to differing vapors which form a porous gel that allows substrates and products to enter and leave the system while immobilizing and retaining the subject biological material (cells, enzymes, liposomes, proteins, or planar lipid bilayers) functional, allowing for unlimited, diverse applications such as drug delivery, biosensors and biofuel cells.
Dr. López’ research focuses on bio-interfacial phenomena, biomaterials, self-assembly and bio-analytical microsystems to address problems in medicine, biotechnology and environmental quality.
ISSUED U. S. PATENTS (UNM-AFFILIATED)
6,660,532 Modular Assembly for Reagentless Affinity Separation and Detection of Analyte, issued December 9, 2003
6,491,061 Stimuli Responsive Hybrid Materials Containing Molecular Actuators and Their Applications, issued December 10, 2002
6,615,855 Stimuli-Responsive Hybrid Materials Containing Molecular Actuators and Their Applications, issued September 9, 2003
6,755,621 Stimuli-Responsive Hybrid Materials Containing Molecular Actuators and Their Applications, issued June 29, 2004
6,471,761 Prototyping of Patterned Functional Nanostructures, issued October 29, 2002
6,913,832 Prototyping of Patterned Functional Nanostructures, issued July 5, 2005
6,673,626 Optoelectronic Circuit for Detecting Changes in Fluorescence Lifetime, issued January 6, 2004
6,685,841 Nanostructured Devices for Separation and Analysis, issued February 3, 2004
6,913,697 Nanostructured Separation and Analysis Devices for Biological Membranes, issued July 5, 2005
RE42,315 Nanostructured Separation and Analysis Devices for Biological Membranes, issued May 3, 2011
RE41,762 Nanostructured Separation and Analysis Devices for Biological Membranes, issued September 28, 2010
RE42,249 Nanostructured Separation and Analysis Devices for Biological Membranes, issued March 29, 2011
7,879,304 Monodisperse Mesoporous Silica Microspheres Formed by Evaporation-Induced Self-Assembly of Surfactant Templates in Aerosols, issued February 1, 2011
7,316,320 Sorting Charged Particles, issued January 8, 2008
7,393,391 Fabrication of Anisotropic Super Hydrophobic/Hydrophilic Nanoporous Membranes, issued July 1, 2008
8,092,595 Self-Assembly of Water Soluble Nanocrystals, issued January 10, 2012
7,465,381 Electrokinetic Molecular Separation in Nanoscale Fluidic Channels, issued December 16, 2008
8,105,471 Nanofluidics for Bioseparation and Analysis, issued January 31, 2012
8,465,983 Detection and Delivery Systems Utilizing Supported Lipid Bilayers, issued June 18, 2013
7,514,267 Detection Systems Utilizing Supported Lipid Bilayers, issued April 7, 2009
8,334,107 Detection Systems Utilizing Supported Lipid Bilayers, issued December 18, 2012
8,114,464 Hybrid Thin Films That Incorporate Lamellar Phospholipid Layer Assemblies and Transmembrane Proteins, issued February 14, 2012
7,959,861 Integrated Affinity Microcolumns and Affinity Capillary Electrophoresis (AMACE), issued June 14, 2011
8,895,321 Integrated Affinity Microcolumns and Affinity Capillary Electrophoresis, issued November 25, 2014
8,455,265 Surface Grafted Conjugated Polymers, issued June 4, 2013
8,252,607 Bio-Compatible Hybrid Organic/Inorganic Gels: Vapor Phase Synthesis, issued August 28, 2012
8,045,140 Method for Multivariate Analysis of Confocal Temporal Image Sequences for Velocity Estimation, issued October 25, 2011
8,753,570 Structure, Synthesis, and Applications for Oligo Phenylene Ethynylenes, issued June 17, 2014
8,658,734 Synthesis of Stable Elastomeric Negative Acoustic Contrast Particles, issued February 25, 2014
9,101,664 Stable Elastomeric Negative Acoustic Contrast Particles and Their Use in Acoustic Radiation Fields, issued August 11, 2015
8,598,053 Materials Incorporating Antimicrobial Polymers, issued December 3, 2013
8,830,451 Multinode Acoustic Focusing for Parallel Flow Cytometry Analysis Applications, issued September 9, 2014
9,074,977 Multinode Acoustic Focusing for Parallel Flow Cytometry Analysis Applications, issued July 7, 2015
9,274,042 Spatially Correlated Light Collection From Multiple Sample Streams Excited With a Line Focused Light Source, issued March 1, 2016
PENDING PATENT APPLICATIONS
Nanopatterned Surface Motility-Based Separations, Removal and Destruction of Bacteria