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Dr. Pope L. Moseley

Chairman, Internal Medicine, Health Sciences Center, UNM


BS – Chemistry, Davidson College, Davidson, NC

MD – University of Illinois College of Medicine

MS – Preventive Medicine, University of Iowa College of Medicine

Business/Research Background

Pope L. Moseley, M.D. holds the Reva S. Skelton Research Endowment of the Department of Internal Medicine and is a Distinguished Professor and a Regents’ Professor of the University of New Mexico. Dr. Moseley has a long history of overseeing clinical and translational research. His research group focuses on the the cellular heat shock protein (HSP) response and adaptation of the whole organism He has conducted basic investigations into the mechanisms of control of the HSPs (Nature, 2000, Am. J. Path, 2008) and the mechanisms by which HSP70 regulates autophagy and inflammation (Am J Physiol, 1997, Cell Stress Chap, 2010, J Biol Chem 2013). Dr. Moseley leads both basic and translational investigations that examine the mechanisms of cellular adaptation using exercise (J Appl Physiol 1991 and 2007, Eur J Appl Physiol 2008 and 2011) to augment the heat shock response and HSF-1 inhibitors in exercising humans to block the heat shock response (Am J Physiol. 2011). As the Associate Director of the University of New Mexico Clinical Translational Science Center (UL1), he oversees the development of Comparative Effectiveness Research and the development of the Health Sciences Center informatics platform. He holds a Visiting Professor appointment in the Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, where he assists in the development of informatics approaches to understand disease progression using the Danish National Health Registry (Nature Comm 2014).

Dr. Moseley is a graduate of Davidson College. He received his MD from the University of Illinois. He also holds an MS in Preventive Medicine and Environmental Health from the University of Iowa. He is board certified by the American Board of Internal Medicine, the American Board of Internal Medicine subspecialty board of Pulmonary Diseases, and by the American Board of Preventive Medicine.

Particular Knowledge and Skills

Dr. Moseley has published more than 100 research manuscripts, reviews, and book chapters. His research focuses on the role of the cellular heat shock protein (HSP) response in adaptation to stresses such as exercise. Using exercise as the stimulus, his research group made the initial observations that alterations in cellular HSP accumulation occur in humans. This HSP accumulation modulates the inflammation that is important in cardiovascular disease, diabetes, and other chronic diseases. He holds a number of patents on methods to purify and synthesize HSP-peptide complexes for therapeutic applications.